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Brings, S.* ; Fleming, T.* ; de Buhr, S.* ; Beijer, B.* ; Lindner, T.* ; Wischnjow, A.* ; Kender, Z.* ; Peters, V.* ; Kopf, S.* ; Haberkorn, U.* ; Mier, W.* ; Nawroth, P.P.

A scavenger peptide prevents methylglyoxal induced pain in mice.

Biochim. Biophys. Acta 1863, 654-662 (2017)
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The reactive metabolite methylglyoxal (MG) has been identified as mediator of pain. Scavenging of free MG and the prevention of MG-derived post-translational modifications may provide a useful therapeutic treatment. An arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) with high proteolytic stability and prolonged circulation was developed for the scavenging of MG. It was shown to reduce the formation of albumin-MG adducts in vitro and prevented MG-induced pain by reducing plasma MG levels through the formation of peptide-MG adducts in vivo. CycK(Myr)R4E therefore presents a promising option for the treatment of pain and other diabetic complications associated with high MG levels.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Diabetic Complications ; Methylglyoxal ; Pain ; Peptide ; Scavenger
ISSN (print) / ISBN 0006-3002
Quellenangaben Volume: 1863, Issue: 3, Pages: 654-662 Article Number: , Supplement: ,
Publisher Elsevier