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Khan, A.* ; Dellago, H.* ; Terlecki-Zaniewicz, L.* ; Karbiener, M.* ; Weilner, S.* ; Hildner, F.* ; Steininger, V.* ; Gabriel, C.* ; Mück, C.* ; Jansen-Dürr, P.* ; Hacobian, A.* ; Scheideler, M. ; Grillari-Voglauer, R.* ; Schosserer, M.* ; Grillari, J.*

SNEVhPrp19/hPso4 regulates adipogenesis of human adipose stromal cells.

Stem Cell Rep. 8, 21-29 (2017)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasion, in adipogenic differentiation of human adipose stromal cells (hASCs). We showed that SNEV is induced during adipogenesis and localized both in the nucleus and in the cytoplasm. Knockdown of SNEV perturbed adipogenic differentiation and led to accumulation of DNA damage in hASCs upon oxidative stress. In addition, we demonstrated that SNEV is required for fat deposition in Caenorhabditis elegans. Consequently, we tested other DDR factors and found that WRN is also required for adipogenesis in both models. These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter SNEV, Prp19, Pso4, adipogenesis, DNA damage repair, WRN, human adipose stromal cells, C. elegans; Mesenchymal Stem-cells; Life-span; Caenorhabditis-elegans; Dna-damage; Adipocyte Differentiation; Protein Complex; Fat; Repair; Pso4; Snev
ISSN (print) / ISBN 2213-6711
Zeitschrift Stem Cell Reports
Quellenangaben Band: 8, Heft: 1, Seiten: 21-29 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Maryland Heights, MO
Begutachtungsstatus Peer reviewed