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Khan, A.* ; Dellago, H.* ; Terlecki-Zaniewicz, L.* ; Karbiener, M.* ; Weilner, S.* ; Hildner, F.* ; Steininger, V.* ; Gabriel, C.* ; Mück, C.* ; Jansen-Dürr, P.* ; Hacobian, A.* ; Scheideler, M. ; Grillari-Voglauer, R.* ; Schosserer, M.* ; Grillari, J.*

SNEVhPrp19/hPso4 regulates adipogenesis of human adipose stromal cells.

Stem Cell Rep. 8, 21-29 (2017)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasion, in adipogenic differentiation of human adipose stromal cells (hASCs). We showed that SNEV is induced during adipogenesis and localized both in the nucleus and in the cytoplasm. Knockdown of SNEV perturbed adipogenic differentiation and led to accumulation of DNA damage in hASCs upon oxidative stress. In addition, we demonstrated that SNEV is required for fat deposition in Caenorhabditis elegans. Consequently, we tested other DDR factors and found that WRN is also required for adipogenesis in both models. These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process.
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Publication type Article: Journal article
Document type Scientific Article
Keywords SNEV, Prp19, Pso4, adipogenesis, DNA damage repair, WRN, human adipose stromal cells, C. elegans; Mesenchymal Stem-cells; Life-span; Caenorhabditis-elegans; Dna-damage; Adipocyte Differentiation; Protein Complex; Fat; Repair; Pso4; Snev
ISSN (print) / ISBN 2213-6711
Quellenangaben Volume: 8, Issue: 1, Pages: 21-29 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Maryland Heights, MO
Reviewing status Peer reviewed