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Xu, G.* ; Hansen, J.S.* ; Zhao, X.J.* ; Chen, S.* ; Hoene, M.* ; Wang, X.L.* ; Clemmesen, J.O.* ; Secher, N.H.* ; Häring, H.-U. ; Pedersen, B.K.* ; Lehmann, R. ; Weigert, C. ; Plomgaard, P.*

Liver and muscle contribute differently to the plasma acylcarnitine pool during fasting and exercise in humans.

J. Clin. Endocrinol. Metab. 101, 5044-5052 (2016)
Verlagsversion Forschungsdaten DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Plasma acylcarnitine levels are elevated by physiological conditions such as fasting and exercise but also in states of insulin resistance and obesity. Aim: To elucidate the contribution of liver and skeletal muscle to plasma acylcarnitines in the fasting state and during exercise in humans. Methods: In 2 independent studies, young healthy males were fasted overnight and performed an acute bout of exercise to investigate either acylcarnitines in skeletal muscle biopsies and arterial-to-venous plasma differences over the exercising and resting leg (n = 9) or the flux over the hepato-splanchnic bed (n = 10). Results: In the fasting state, a pronounced release of C2- and C3-carnitines from the hepatosplanchnic bed and an uptake of free carnitine by the legs were detected. Exercise further increased the release of C3-carnitine from the hepato-splanchnic bed and the uptake of free carnitine in the exercising leg. In plasma and in the exercising muscle, exercise induced an increase of most acylcarnitines followed by a rapid decline to preexercise values during recovery. In contrast, free carnitine was decreased in the exercising muscle and quickly restored thereafter. C8-, C10-, C10: 1-, C12-, and C12: 1-carnitines were released from the exercising leg and simultaneously; C6, C8, C10, C10: 1, C14, and C16: 1 were taken up by the hepato-splanchnic. Conclusion: These data provide novel insight to the organo-specific release/uptake of acylcarnitines. The liver is a major contributor to systemic short chain acylcarnitines, whereas the muscle tissue releases mostly medium chain acylcarnitines during exercise, indicating that other tissues are contributing to the systemic increase in long chain acylcarnitines.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Amino-acid-metabolism; Human Skeletal-muscle; To-insulin Ratio; Fatty-acid; Carnitine; Substrate; Obesity; Signatures; Oxidation; Reflect
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Quellenangaben Band: 101, Heft: 12, Seiten: 5044-5052 Artikelnummer: , Supplement: ,
Verlag Endocrine Society
Verlagsort Bethesda, Md.
Begutachtungsstatus Peer reviewed