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Bardot, E.* ; Calderon, D.* ; Santoriello, F.* ; Han, S.* ; Cheung, K.* ; Jadhav, B.* ; Burtscher, I. ; Artap, S.* ; Jain, R.K.* ; Epstein, J.A.* ; Lickert, H. ; Gouon-Evans, V.* ; Sharp, A.J.* ; Dubois, N.C.*

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.

Nat. Commun. 8:14428 (2017)
Verlagsversion Forschungsdaten Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (<5%) of the differentiated heart. These progenitors are specified during gastrulation, when they transiently express Foxa2, a gene not previously implicated in cardiac development. Importantly, Foxa2+ cells contribute to previously identified progenitor populations in a defined pattern and ratio. Lastly, we describe an analogous Foxa2+ population during differentiation of embryonic stem cells. Together, these findings provide insight into the developmental origin of ventricular and atrial cells, and may lead to the establishment of new strategies for generating chamber-specific cell types from pluripotent stem cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Stem-cell Differentiation; Primitive Streak; Heart Development; Myocardial-cells; Mammalian Heart; Mouse Heart; Expression; Morphogenesis; Endoderm; Field
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 8, Heft: , Seiten: , Artikelnummer: 14428 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed