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Yaroshenko, A.* ; Meinel, F.G.* ; Bech, M.* ; Tapfer, A.* ; Velroyen, A.* ; Schleede, S.* ; Müller, M.* ; Auweter, S.* ; Bohla, A. ; Yildirim, A.Ö. ; Nilolaou, K.* ; Bamberg, F.* ; Eickelberg, O. ; Reiser, M.* ; Pfeiffer, F.*

Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation.

In: (IEEE 10th International Symposium on Biomedical Imaging (ISBI), 2013, 7-11 April 2013). 2013. 370-373
Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an X-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and darkfield signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and darkfield signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.
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Publikationstyp Artikel: Konferenzbeitrag
Schlagwörter Lungs, X-ray imaging, Gratings, Computed tomography, Absorption, Scattering
ISBN 978-1-4673-6455-3
Konferenztitel IEEE 10th International Symposium on Biomedical Imaging (ISBI), 2013
Konferzenzdatum 7-11 April 2013
Quellenangaben Band: , Heft: , Seiten: 370-373 Artikelnummer: , Supplement: ,