PuSH - Publikationsserver des Helmholtz Zentrums München

Schnitzler, M.M.Y.* ; Storch, U.* ; Gudermann, T.

Mechanosensitive G(q/11) protein-coupled receptors mediate myogenic vasoconstriction.

Microcirc. 23, 621-625 (2016)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Myogenic vasoconstriction (Bayliss effect) is mediated by vascular smooth muscle cells (VSMCs) of small resistance arteries sensing mechanical forces. During the last three decades, several proteins have been proposed as VSMC mechanosensors. Our previous studies highlighted agonist-independent mechanical activation of G(q/11) protein-coupled receptors (G(q/11)PCRs) in VSMCs of resistance arteries. In particular, angiotensin II AT1 receptors (AT(1)Rs) emerged as mechanosensors mediating myogenic tone. Moreover, we found that the AT(1B) receptor isoform was more mechanosensitive than the AT(1A) receptor. Interestingly, cysteinyl leukotriene 1 receptors (CysLT(1)Rs) were up-regulated in AT(1)R-deficient arteries as an essential backup strategy to compensate for the loss of vasoconstrictor receptors. Up-regulation of CysLT(1)Rs resulted in increased myogenic tone at low intraluminal pressures resulting in hyperactivity of AT(1)R-deficient arteries. Only at high intraluminal pressures myogenic tone was reduced, thus reflecting the loss of AT(1)Rs. Further, CysLT(1)Rs were involved in myogenic vasoconstriction of wild-type arteries. Simultaneous blockade of AT(1)Rs and CysLT(1)Rs in wild-type arteries caused reduction in myogenic tone of more than 60% comparable to the application of the selective G(q/11)protein inhibitor YM-254890. Our findings suggest that AT(1)Rs and CysLT(1)Rs are crucial mechanosensors in resistance arteries mediating 60% of myogenic vasoconstriction via the G(q/11)-protein pathway without involvement of endogenous agonists.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Gpcrs ; Mechanosensation ; Myogenic Vasoconstriction; Angiotensin-ii; Type-1 Receptor; Pressure; Mouse; Gene; Activation; Inhibitor; Channels; Arteries; Cells
ISSN (print) / ISBN 1073-9688
e-ISSN 1549-8719
Zeitschrift Microcirculation
Quellenangaben Band: 23, Heft: 8, Seiten: 621-625 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Malden, Mass.
Begutachtungsstatus