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Iron and ferroptosis: A still ill-defined liaison.

IUBMB Life 69, 423-434 (2017)
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Ferroptosis is a recently described form of regulated necrotic cell death, which appears to contribute to a number of diseases, such as tissue ischemia/reperfusion injury, acute renal failure, and neurodegeneration. A hallmark of ferroptosis is iron-dependent lipid peroxidation, which can be inhibited by the key ferroptosis regulator glutathione peroxidase 4(Gpx4), radical trapping antioxidants and ferroptosis-specific inhibitors, such as ferrostatins and liproxstatins, as well as iron chelation. Although great strides have been made towards a better understanding of the proximate signals of distinctive lipid peroxides in ferroptosis, still little is known about the mechanistic implication of iron in the ferroptotic process. Hence, this review aims at summarizing recent advances in our understanding to what is known about enzymatic and nonenzymatic routes of lipid peroxidation, the involvement of iron in this process and the identification of novel players in ferroptotic cell death. Additionally, we review early works carried out long time before the term "ferroptosis" was actually introduced but which were instrumental in a better understanding of the role of ferroptosis in physiological and pathophysiological contexts.
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Publication type Article: Journal article
Document type Review
Keywords Gpx4 ; Electrophile Signaling ; Ferritinophagy ; Glutathione Peroxidase 4 ; Labile Iron Pool ; Lipid Peroxidation ; Regulated Necrosis; Glutathione-peroxidase 4; Cystine/glutamate Exchange Transporter; Nonapoptotic Cell-death; Amino-acid Transporter; Lipid-peroxidation; Oxidative Stress; Glutamate Toxicity; Human-fibroblasts; Plasma-membrane; System X(c)(-)
ISSN (print) / ISBN 0158-5231
e-ISSN 1521-6551
Journal IUBMB Life
Quellenangaben Volume: 69, Issue: 6, Pages: 423-434 Article Number: , Supplement: ,
Publisher Taylor & Francis
Publishing Place Hoboken
Reviewing status Peer reviewed