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Varela, L.* ; Suyama, S.* ; Huang, Y.* ; Shanabrough, M.* ; Tschöp, M.H. ; Gao, X.B.* ; Giodano, F.J.* ; Horvath, T.L.

Endothelial HIF-1α enables hypothalamic glucose uptake to drive POMC neurons.

Diabetes 66, 1511-1520 (2017)
Verlagsversion Forschungsdaten DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Glucose is the primary driver of hypothalamic POMC neurons. Here, we show that endothelial HIF-1α controls glucose uptake in the hypothalamus, and, that it is up-regulated in conditions of under-nourishment during which POMC neuronal activity is decreased. Endothelium-specific knockdown of HIF-1α impairs the ability of POMC neurons to adapt to the changing metabolic environment in vivo resulting in overeating of mice after food deprivation. The impaired functioning of POMC neurons was reversed ex vivo or by parenchymal glucose administration. These observations indicate an active role for endothelial cells in the central control of metabolism and suggest that central vascular impairments may cause metabolic disorders.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Agrp Neurons; Leptin Resistance; Brain; Acid; Availability; Transporters; Hif-1-alpha; Homeostasis; Signals; Barrier
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 66, Heft: 6, Seiten: 1511-1520 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed