PuSH - Publication Server of Helmholtz Zentrum München

Dai, B.* ; Grau, M.* ; Juilland, M.* ; Klener, P.* ; Höring, E.* ; Molinsky, J.* ; Schimmack, G. ; Aukema, S.M.* ; Hoster, E.* ; Vogt, N.* ; Staiger, A.M.* ; Erdmann, T.* ; Xu, W.* ; Erdmann, K.* ; Dzyuba, N.* ; Madle, H.* ; Berdel, W.E.* ; Trneny, M.* ; Dreyling, M.* ; Jöhrens, K.* ; Lenz, P.* ; Rosenwald, A.* ; Siebert, R.* ; Tzankov, A.* ; Klapper, W.* ; Anagnostopoulos, I.* ; Krappmann, D. ; Ott, G.* ; Thome, M.* ; Lenz, G.*

B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.

Blood 129, 333-346 (2017)
Publ. Version/Full Text DOI
Open Access Green as soon as Postprint is submitted to ZB.
Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by poor clinical outcome. Recent studies revealed the importance of B-cell receptor (BCR) signaling in maintaining MCL survival. However, it remains unclear which role MALT1, an essential component of the CARD11-BCL10-MALT1 complex that links BCR signaling to the NF-κB pathway, plays in the biology of MCL. Here we show that a subset of MCLs is addicted to MALT1, as its inhibition by either RNA or pharmacologic interference induced cytotoxicity both in vitro and in vivo. Gene expression profiling following MALT1 inhibition demonstrated that MALT1 controls an MYC-driven gene expression network predominantly through increasing MYC protein stability. Thus, our analyses identify a previously unappreciated regulatory mechanism of MYC expression. Investigating primary mouse splenocytes, we could demonstrate that MALT1-induced MYC regulation is not restricted to MCL, but represents a common mechanism. MYC itself is pivotal for MCL survival because its downregulation and pharmacologic inhibition induced cytotoxicity in all MCL models. Collectively, these results provide a strong mechanistic rationale to investigate the therapeutic efficacy of targeting the MALT1-MYC axis in MCL patients.
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords Nf-kappa-b; Paracaspase Malt1; T-cells; Activation; Cleavage; Lubac; Pathogenesis; Survival; Proliferation; Inactivation
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Journal Blood
Quellenangaben Volume: 129, Issue: 3, Pages: 333-346 Article Number: , Supplement: ,
Publisher American Society of Hematology
Publishing Place Washington
Reviewing status Peer reviewed