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Ding, L ; Dean-Ben, X.L. ; Burton, N.C.B.* ; Sobol, R.W.* ; Ntziachristos, V. ; Razansky, D.

Non-negative constrained inversion approaches for unmixing chromophores in multispectral optoacoustic tomography.

Proc. SPIE 10064:100641B (2017)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Due to modeling and experimental imperfections, multispectral optoacoustic tomography images are often afflicted with negative values, which are further amplified when propagating into the spectrally unmixed images of chromophore concentrations. Since negative values have no physical meaning, accuracy can potentially be improved by imposing non-negativity constraints on the initial reconstructions and the unmixing steps. Herein, we compare several non-negative constrained approaches with reconstruction and spectral unmixing performed separately or combined in a single inverse step. The quantitative performance and sensitivity of the different approaches in detecting small amounts of spectrally-distinct chromophores are studied in tissue-mimicking phantoms and mouse experiments.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Optoacoustic/photoacoustic tomography, multispectral imaging, spectral unmixing, non-negative constraint
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Konferenztitel Photons Plus Ultrasound: Imaging and Sensing 2017
Konferzenzdatum 28 January - 2 February 2017
Konferenzort San Francisco, California, United States
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 10064, Heft: , Seiten: , Artikelnummer: 100641B Supplement: ,
Verlag SPIE
Begutachtungsstatus Peer reviewed