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Molecular imaging probes for multi-spectral optoacoustic tomography.

Chem. Commun. 53, 4653-4672 (2017)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Multi-Spectral Optoacoustic Tomography (MSOT) merges the power of high-resolution imaging at tissue depths of several millimeters to centimeters with the advantages of optical imaging, in large part by exploiting spectral detection of endogenous molecules in tissue or exogenous photoabsorbing probes. Current advances in fast-tuning laser technology, image reconstruction and spectral detection schemes have yielded real-time optoacoustic (photoacoustic) imaging spanning applications from microscopy to human imaging. This progress has generated an unprecedented need for imaging probes and reporter gene approaches optimized for optoacoustic signal generation. New classes of probes are emerging and create new opportunities for visualizing morphological and pathophysiological features in vivo, in a non-invasive manner. Here we review recent progress in optoacoustic probes and discuss applications and challenges for biological imaging as well as prospects for clinical translation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Photoacoustic Contrast Agent; Surface-plasmon Resonance; Iron-oxide Nanoparticles; Sentinel Lymph-node; Semiconducting Polymer Nanoparticles; Copper Sulfide Nanoparticles; Guided Photothermal Therapy; Ray Computed-tomography; Brain-tumor Delineation; Hollow Gold Nanospheres
ISSN (print) / ISBN 0009-241X
e-ISSN 1364-548X
Quellenangaben Band: 53, Heft: 34, Seiten: 4653-4672 Artikelnummer: , Supplement: ,
Verlag Royal Society of Chemistry (RSC)
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed