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Lung carcinogenesis and fibrosis taken together: Just coincidence?

Curr. Opin. Pulm. Med. 23, 290-297 (2017)
Postprint DOI PMC Verlagsversion bestellen
Open Access Green
PURPOSE OF REVIEW: The pathogenesis of lung cancer and pulmonary fibrotic disorders partially overlaps. This review focuses on the common features of the two disease categories, aimed at advancing our translational understanding of their pathobiology and at fostering the development of new therapies. RECENT FINDINGS: Both malignant and collagen-producing lung cells display enhanced cellular proliferation, increased resistance to apoptosis, a propensity for invading and distorting the lung parenchyma, as well as stemness potential. These characteristics are reinforced by the tissue microenvironment and inflammation seems to play an important adjuvant role in both types of disorders. SUMMARY: Unraveling the thread of the common and distinct characteristics of lung fibrosis and cancer might contribute to a more comprehensive approach of the pathobiology of both diseases and to a pathfinder for novel and personalized therapeutic strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Carcinoma ; Fibroblast ; Hallmarks ; Nuclear Factor-kappa B ; Scar; Idiopathic Pulmonary-fibrosis; Epithelial-mesenchymal Transition; Fas-induced Apoptosis; Extracellular-matrix; Stem-cells; In-vitro; Cancer Progression; Tissue-repair; Clinical Characteristics; Fibroblast Accumulation
ISSN (print) / ISBN 1070-5287
Zeitschrift Current opinion in Pulmonary Medicine
Quellenangaben Band: 23, Heft: 4, Seiten: 290-297 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Verlagsort Philadelphia
Begutachtungsstatus