Open Access Green as soon as Postprint is submitted to ZB.
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.
Neuron 52, 437-444 (2006)
Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage. © 2006 Elsevier Inc. All rights reserved.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Proteins ; Signaling ; Sysneuro
ISSN (print) / ISBN 0896-6273
Quellenangaben Volume: 52, Issue: 3, Pages: 437-444
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) CCG Molecular Neurogenetics (IDG-KMN)