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Ghita, M.A.* ; Caruntu, C.* ; Lixandru, D.* ; Pitea, A. ; Batani, A.* ; Boda, D.*

The quest for novel biomarkers in early diagnosis of diabetic neuropathy.

Current proteomics 14, 86-99 (2017)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Diabetic neuropathy is the most common complication of diabetes mellitus and a major factor associated with foot ulcers and amputations in patients with diabetes. Diagnosing diabetic neuropathy in early stages may reduce the risk for comorbidities. However, it still represents a major challenge for the healthcare providers, despite the complexity of available techniques. Discovering new serum biomarkers, useful for early diagnosis of diabetic neuropathy and monitoring the disease progression is of growing interest for the scientific research. In this regard, the field of proteomics is extremely promising. Mass spectrometry technology and bioinformatic analysis of proteomic data accelerated the detection of biomarkers related to peripheral nervous system pathology. Herein, we analyze what role proteomics approaches play in the modern diagnostic strategy of diabetic neuropathy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Biomarker ; Diabetes ; Diabetic Neuropathy ; Diagnosis ; Mass Spectrometry ; Proteomics; Nerve Growth-factor; Gene-related Peptide; Phosphorylated Neurofilament-heavy; Unmyelinated Primary Afferents; Impaired Glucose-tolerance; Neuron-specific Enolase; Isolated-perfused Heart; Small-fiber Neuropathy; Potential Vanilloid 1; Quality-of-life
ISSN (print) / ISBN 1570-1646
e-ISSN 1875-6247
Zeitschrift Current proteomics
Quellenangaben Band: 14, Heft: 2, Seiten: 86-99 Artikelnummer: , Supplement: ,
Verlag Bentham Science Publishers
Verlagsort San Francisco, Calif.
Begutachtungsstatus Peer reviewed