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Budinger, G.S.* ; Kohanski, R.A.* ; Gan, W.* ; Kobor, M.S.* ; Amaral, L.A.* ; Armanios, M.* ; Kelsey, K.T.* ; Pardo, A.* ; Tuder, R.M.* ; Macián, F.* ; Chandel, N.S.* ; Vaughan, D.* ; Rojas, M.* ; Mora, A.L.* ; Kovacs, E.* ; Duncan, S.R.* ; Finkel, T.* ; Choi, A.* ; Eickelberg, O. ; Chen, D.* ; Agusti, A.* ; Selman, M.* ; Balch, W.E.* ; Busse, P.J.* ; Lin, A.* ; Morimoto, R.* ; Sznajder, J.I.* ; Thannickal, V.J.*

The intersection of aging biology and the pathobiology of lung diseases: A joint NHLBI/NIA Workshop.

J. Gerontol. A Biol. Sci. Med. Sci., accepted (2017)
Verlagsversion Postprint DOI PMC
Open Access Green
Death from chronic lung disease is increasing and Chronic Obstructive Pulmonary Disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as lifespan. This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology. These investigators encouraged the use of genetic systems and aged animals in the study of lung disease and the development of integrative systems-based platforms that can dynamically incorporate datasets that describe the genomics, transcriptomics, epigenomics, metabolomics and proteomics of the aging lung in health and disease. Further research was recommended to integrate benchmark biological hallmarks of aging in the lung with the pathobiology of acute and chronic lung diseases with divergent pathologies for which advanced age is the most important risk factor.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1079-5006
e-ISSN 1758-535X
Zeitschrift Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Verlag Oxford University Press
Begutachtungsstatus