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Prolonged pro-inflammatory effects of ultrafine particles in the lung of allergic asthmatics.
Am. J. Respir. Crit. Care Med. 179:A1308 (2009)
Introduction/Rationale Epidemiological studies have shown that exposure to ambient particles is associated with increased respiratory symptoms and exacerbations in asthmatic patients. Ultrafine particles (UFP) may contribute to these negative health effects due to their highly reactive surface area and oxidant capacity. The aim of this study was to test the hypothesis that the allergic inflammation in the lung of allergic asthmatics will be enhanced due to the preexposure to UFP. Methods 14 mild allergic asthmatics were exposed for 2 hours to a controlled atmosphere of 50μg/m 3 spark−discharge generated carbon black UFP (Ø50nm) or clean air in a randomized, double−blind crossover design. The expositions were performed with a wash−out period of 30 days under intermittent bicycles ergometer exercise. 18 hours after the exposures segmental allergen challenges were performed by bronchoscopy. 42 hours after the expositions, during a second bronchoscopy, the previously challenged segments were lavaged and BAL−cells were obtained for differentiated FACS analysis and oxygen radical generation by chemiluminescence. Results The preexposition to UFP showed only a slight non significant short term effect after 42 hours on the allergic inflammation compared to the exposition with clean air. The subgroup of subjects however, which were exposed to UFP in the first period and to clean air in the second period showed after the allergen challenge in the second period a strong increase in the absolute numbers of eosinophils and oxygen radical generation by BAL−cells. Conclusions of the study The exposure to UFP 30 days prior to an allergen challenge had a strong pro−inflammatory effect on the allergic inflammation in allergic asthmatics.
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Publication type Article: Journal article
Document type Meeting abstract
ISSN (print) / ISBN 1073-449X
Quellenangaben Volume: 179, Article Number: A1308
Publisher American Thoracic Society
Reviewing status Peer reviewed