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Brings, S.* ; Fleming, T. ; Freichel, M.* ; Muckenthaler, M.U.* ; Herzig, S. ; Nawroth, P.P.

Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention.

Int. J. Mol. Sci. 18:984 (2017)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter 3-deoxyglucosone ; Advanced Glycation End-products ; Aldose Reductase ; Diabetes ; Glyoxal ; Glyoxalase ; Methylglyoxal
ISSN (print) / ISBN 1422-0067
e-ISSN 1661-6596
Quellenangaben Band: 18, Heft: 5, Seiten: , Artikelnummer: 984 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed