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Kaess, B.M.* ; de Las Heras Gala, T. ; Zierer, A. ; Meisinger, C. ; Wahl, S. ; Peters, A. ; Todd, J.A.* ; Herder, C.* ; Huth, C. ; Thorand, B. ; Koenig, W.*

Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population.

Eur. J. Epidemiol. 32, 583–591 (2017)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Troponins are sensitive markers of myocardial injury and predictive of cardiovascular events, but conventional assays fail to detect slightly elevated troponins in a considerable proportion of the general population. Using a novel ultrasensitive assay, we explored the relationship of troponin levels with the incidence of coronary heart disease (CHD) in a case-cohort sample (mean age 52.5 ± 0.2 years, 51.5% women) comprising 803 CHD cases and 1942 non-cases. Ultrasensitive troponin I was detectable in 99.9% of available case-cohort samples. In an age- and sex-adjusted model, individuals in the highest quartile of the troponin distribution had a more than threefold increased risk for CHD events compared to those in the bottom quartile [hazard ratio, HR, 3.11; 95% confidence interval (CI) 2.15-4.49]. In a model adjusting for cardiovascular risk factors including C-reactive protein, cystatin C and N-terminal pro brain natriuretic peptide, individuals in the highest troponin I quartile still showed a hazard ratio of 2.58 (95% CI 1.66-4.00) for incident CHD as compared to those in the lowest quartile. Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Coronary Heart Disease ; General Population ; Risk Prediction ; Ultrasensitive Troponin I; C-reactive Protein; Monica Augsburg Cohort; Myocardial-infarction; Risk Prediction; Multiple Imputation; Natriuretic Peptide; Survival Analysis; Assay; Mortality; Values
ISSN (print) / ISBN 0393-2990
e-ISSN 1573-7284
Quellenangaben Band: 32, Heft: 7, Seiten: 583–591 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Dordrecht
Begutachtungsstatus Peer reviewed