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Jatzlauk, G.* ; Bartel, S.* ; Heine, H.* ; Schloter, M. ; Krauss-Etschmann, S.*

Influences of environmental bacteria and their metabolites on allergies, asthma and host microbiota.

Allergy 72, 1859-1867 (2017)
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The prevalence of allergic diseases and asthma has dramatically increased over the last decades, resulting in a high burden for patients and health care systems. Thus, there is an unmet need to develop preventative strategies for these diseases. Epidemiological studies show that reduced exposure to environmental bacteria in early life (e.g birth by cesarian section, being formula-fed, growing up in an urban environment or with less contact to various persons) is associated with an increased risk to develop allergies and asthma later in life. Conversely, a reduced risk for asthma is consistently found in children growing up on traditional farms, thereby being exposed to a wide spectrum of microbes. However, clinical studies are still rare and to some extent contradicting. A detailed mechanistic understanding how environmental microbes influence the development of the human microbiome and the immune system is important to enable the development of novel preventative approaches that are based on the early modulation of the host microbiota and immunity. In this mini-review we summarize current knowledge and experimental evidence for the potential of bacteria and their metabolites to be used for the prevention of asthma and allergic diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Asthma ; Environment And Hygiene Hypothesis ; Prevention; Placebo-controlled Trial; Randomized Controlled-trials; Day-care Attendance; Regulatory T-cells; Childhood Asthma; Atopic-dermatitis; Cesarean-section; Gut Microbiota; Early-life; Double-blind
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Zeitschrift Allergy
Quellenangaben Band: 72, Heft: 12, Seiten: 1859-1867 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed