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Direct neuronal reprogramming: Achievements, hurdles, and new roads to success.

Cell Stem Cell 21, 18-34 (2017)
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The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent advances in understanding and overcoming hurdles to direct neuronal conversion have provided new insights into mechanisms that maintain cell identity programs and have enabled high efficiency reprogramming in vivo. We discuss key cell-intrinsic molecular and metabolic constraints that influence the establishment of a new identity as well as environmental inputs from injured brains that favor or harm the conversion process. Finally, we outline the challenges ahead with a particular focus on direct neuronal reprogramming in vivo.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Brain Repair ; Conversion ; Direct Reprogramming ; Ipsc ; Metabolism ; Neurogenesis ; Neuron ; Stem Cells ; Transdifferentiation; Pluripotent Stem-cells; Traumatic Brain-injury; Microglia/macrophage Polarization Dynamics; Chromatin-remodeling Complexes; Neural Stem/progenitor Cells; Elegans Germ-cells; In-vivo; Direct Conversion; Functional-neurons; Human Fibroblasts
ISSN (print) / ISBN 1934-5909
e-ISSN 1875-9777
Journal Cell Stem Cell
Quellenangaben Volume: 21, Issue: 1, Pages: 18-34 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed