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Cellular and molecular mechanisms coordinating pancreas development.

Development 144, 2873-2888 (2017)
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The pancreas is an endoderm-derived glandular organ that participates in the regulation of systemic glucose metabolism and food digestion through the function of its endocrine and exocrine compartments, respectively. While intensive research has explored the signaling pathways and transcriptional programs that govern pancreas development, much remains to be discovered regarding the cellular processes that orchestrate pancreas morphogenesis. Here, we discuss the developmental mechanisms and principles that are known to underlie pancreas development, from induction and lineage formation to morphogenesis and organogenesis. Elucidating such principles will help to identify novel candidate disease genes and unravel the pathogenesis of pancreas-related diseases, such as diabetes, pancreatitis and cancer.
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Publication type Article: Journal article
Document type Review
Keywords Diabetes ; Endocrine Cells ; Exocrine Cells ; Islets Of Langerhans ; Lineage Formation ; Morphogenesis ; Organogenesis ; Pancreas Development ; β-cells; Endocrine Progenitor Cells; Vertebrate Endoderm Development; Neonatal Diabetes-mellitus; Adult-mouse Pancreas; Beta-cells; Transcription Factor; In-vitro; Alpha-cell; Fate Specification; Exocrine Pancreas
Reviewing status