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Zscheppang, K.* ; Berg, J.V.* ; Hedtrich, S.* ; Verheyen, L.* ; Wagner, D.E. ; Suttorp, N.* ; Hippenstiel, S.* ; Hocke, A.C.*

Human pulmonary 3D models for translational research.

Biotechnol. J. 13:1700341 (2018)
Open Access Green as soon as Postprint is submitted to ZB.
Lung diseases belong to the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modeling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal usage in biomedical research.
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Publication type Article: Journal article
Document type Review
Keywords 3d Models ; Alveolar ; Bronchial ; Human Lung Tissue ; Infections; Human Lung-tissue; Slow-reacting Substance; Airway Epithelial-cells; Nontypable Haemophilus-influenzae; Pluripotent Stem-cells; Human Isolated Bronchi; In-vitro Models; Organs-on-chips; Cigarette-smoke; Animal-models
ISSN (print) / ISBN 1860-6768
Quellenangaben Volume: 13, Issue: 1, Pages: , Article Number: 1700341 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed