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Spella, M.* ; Marazioti, A.* ; Arendt, K.A.M. ; Stathopoulos, G.T.

RAS oncogenes direct metastasis.

Mol. Cell. Oncol. 4:e1345711 (2017)
DOI Order publishers version
RAS genes are cardinal driver oncogenes frequently and differentially mutated across bodily tumors. Their tumorigenic potential has been mainly ascribed to autonomous promotion of tumor cell proliferation and survival. However, recent evidence shows that RAS oncogenes also function to define metastatic tropism. Interestingly, RAS-driven metastasis is mediated by distinct chemokine sets that signal to endothelial and myeloid cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Chemokines ; Kras ; Lung Metastasis ; Malignant Pleural Effusion ; Nras
e-ISSN 2372-3556
Quellenangaben Volume: 4, Issue: 5, Pages: , Article Number: e1345711 Supplement: ,
Publisher Taylor & Francis
Reviewing status Peer reviewed