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RAS oncogenes direct metastasis.
Mol. Cell. Oncol. 4:e1345711 (2017)
RAS genes are cardinal driver oncogenes frequently and differentially mutated across bodily tumors. Their tumorigenic potential has been mainly ascribed to autonomous promotion of tumor cell proliferation and survival. However, recent evidence shows that RAS oncogenes also function to define metastatic tropism. Interestingly, RAS-driven metastasis is mediated by distinct chemokine sets that signal to endothelial and myeloid cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Chemokines ; Kras ; Lung Metastasis ; Malignant Pleural Effusion ; Nras
Journal Molecular & Cellular Oncology
Quellenangaben Volume: 4, Issue: 5, Article Number: e1345711
Publisher Taylor & Francis
Reviewing status Peer reviewed
Institute(s) Institute of Lung Biology (ILBD)