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Michalke, B. ; Willkommen, D. ; Drobyshev, E.* ; Solovyev, N.*

The importance of speciation analysis in neurodegeneration research.

Trends Analyt. Chem. 104, 160-170 (2017)
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Open Access Green
Element speciation offers deeper insight into the molecular mechanisms of disease by determining element species pattern. Thus, having great potential for investigating neurodegeneration in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and mild cognitive impairment, speciation is increasingly considered in epidemiological or clinical neurological studies. This review analyses recent speciation findings in neurodegeneration research, concentrating on measurements in cerebrospinal fluid and brain. Elements considered are aluminum, arsenic, copper, iron, mercury, manganese, selenium and zinc. Also interactions of trace element species are discussed briefly. Typically, hyphenated techniques are used in neurodegeneration speciation studies. The results allow sorting-out less important species from compounds significant for the disease, with subsequent use of molecular biology methods to uncover the exact mechanisms. This review indicates the trend of combining speciation and neuroscience and provides a sketch about data and outcomes. For brain research, we recommend using modern, powerful techniques throughout which provide advanced validity and information in a chemical sense.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Speciation ; Neurodegeneration ; Cerebrospinal Fluid ; Brain ; Hyphenated Techniques ; Inductively Coupled Plasma Mass Spectrometry ; High Pressure Liquid Chromatography ; Trace Element ; Redox Stability ; Quality Control; Plasma-mass Spectrometry; Cerebrospinal-fluid Selenium; Lateral-sclerosis Patients; Alzheimers-disease; Selenoprotein-p; Parkinsons-disease; Isotope-dilution; Brain-tissue; Icp-ms; Chemical Speciation
ISSN (print) / ISBN 0165-9936
e-ISSN 1873-3689
Quellenangaben Band: 104, Heft: , Seiten: 160-170 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Begutachtungsstatus Peer reviewed