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Esparza-Gordillo, J.* ; Weidinger, S. ; Fölster-Holst, R.* ; Bauerfeind, A.* ; Ruschendorf, F.* ; Patone, G.* ; Rohde, K.* ; Marenholz, I.* ; Schulz, F.* ; Kerscher, T.* ; Hubner, N.* ; Wahn, U.* ; Schreiber, S.* ; Franke, A.* ; Vogler, R.* ; Heath, S.* ; Baurecht, H. ; Novak, N.* ; Rodriguez, E. ; Illig, T. ; Lee-Kirsch, M.-A.* ; Ciechanowicz, A.* ; Kurek, M.* ; Piskackova, T.* ; Macek, M.* ; Lee, Y.-A.* ; Ruether, A.*

A common variant on chromosome 11q13 is associated with atopic dermatitis.

Nat. Genet. 41, 596-601 (2009)
Open Access Green as soon as Postprint is submitted to ZB.
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P-combined = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.
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Publication type Article: Journal article
Document type Scientific Article
Keywords genome-wide association; crohns-disease; filaggrin mutations; ulcerative-colitis; complex; asthma; eczema; genes; expression; children
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 5, Pages: 596-601 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed