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Corradini, S.* ; Ballhausen, H.* ; Weingandt, H.* ; Freislederer, P.* ; Schönecker, S.* ; Niyazi, M.* ; Simonetto, C. ; Eidemüller, M. ; Ganswindt, U.* ; Belka, C.*

Left-sided breast cancer and risks of secondary lung cancer and ischemic heart disease.

Strahlenther. Onkol. 194, 196-205 (2017)
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Open Access Green as soon as Postprint is submitted to ZB.
Modern breast cancer radiotherapy techniques, such as respiratory-gated radiotherapy in deep-inspiration breath-hold (DIBH) or volumetric-modulated arc radiotherapy (VMAT) have been shown to reduce the high dose exposure of the heart in left-sided breast cancer. The aim of the present study was to comparatively estimate the excess relative and absolute risks of radiation-induced secondary lung cancer and ischemic heart disease for different modern radiotherapy techniques. Four different treatment plans were generated for ten computed tomography data sets of patients with left-sided breast cancer, using either three-dimensional conformal radiotherapy (3D-CRT) or VMAT, in free-breathing (FB) or DIBH. Dose-volume histograms were used for organ equivalent dose (OED) calculations using linear, linear-exponential, and plateau models for the lung. A linear model was applied to estimate the long-term risk of ischemic heart disease as motivated by epidemiologic data. Excess relative risk (ERR) and 10-year excess absolute risk (EAR) for radiation-induced secondary lung cancer and ischemic heart disease were estimated for different representative baseline risks. The DIBH maneuver resulted in a significant reduction of the ERR and estimated 10-year excess absolute risk for major coronary events compared to FB in 3D-CRT plans (p = 0.04). In VMAT plans, the mean predicted risk reduction through DIBH was less pronounced and not statistically significant (p = 0.44). The risk of radiation-induced secondary lung cancer was mainly influenced by the radiotherapy technique, with no beneficial effect through DIBH. VMAT plans correlated with an increase in 10-year EAR for radiation-induced lung cancer as compared to 3D-CRT plans (DIBH p = 0.007; FB p = 0.005, respectively). However, the EARs were affected more strongly by nonradiation-associated risk factors, such as smoking, as compared to the choice of treatment technique. The results indicate that 3D-CRT plans in DIBH pose the lowest risk for both major coronary events and secondary lung cancer.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Deep Inspiration Breath-hold ; Secondary Cancer ; Myocardial Ischemia ; Three-dimensional Conformal Radiotherapy ; Volumetric-modulated Arc Radiotherapy; Intensity-modulated Radiotherapy; Relative Seriality Model; Term Cardiac Mortality; 20-year Follow-up; Radiation-therapy; Conserving Surgery; Circulatory Disease; Dose Reduction; Arc Therapy; Hold Dibh
ISSN (print) / ISBN 0179-7158
e-ISSN 1439-099X
Quellenangaben Volume: 194, Issue: 3, Pages: 196-205 Article Number: , Supplement: ,
Publisher Urban & Vogel
Publishing Place Heidelberg
Reviewing status Peer reviewed