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MSX1-induced neural crest-like reprogramming promotes melanoma progression.

J. Invest. Dermatol. 138, 141-149 (2018)
Publishers Version Postprint DOI PMC
Open Access Green
as soon as is submitted to ZB.
Melanoma cells share many biological properties with neural crest stem cells. Here we show that the homeodomain transcription factor Msh homeobox 1 (MSX1), which is significantly correlated with melanoma disease progression, reprograms melanocytes and melanoma cells towards a neural crest precursor-like state. MSX1-reprogrammed normal human melanocytes express the neural crest marker p75 and become multipotent. MSX1 induces a phenotypic switch in melanoma, which is characterized by an oncogenic transition from an E-cadherin-high non-migratory state towards a ZEB1-high invasive state. ZEB1 up-regulation is responsible for the MSX1-induced migratory phenotype in melanoma cells. Depletion of MSX1 significantly inhibits melanoma metastasis in vivo. These results demonstrate that neural crest-like reprogramming achieved by a single factor is a critical process for melanoma progression.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Mesenchymal Stem-cells; Transcription Factor; Liver-diseases; Expression; Cancer; Microphthalmia; Melanocytes; Phenotype; Gene; Msx1
Reviewing status