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Mitochondrial adaptation in steatotic mice.

Mitochondrion, accepted (2018)
Open Access Green as soon as Postprint is submitted to ZB.
Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Mitochondria ; Nafld ; Steatosis ; Western Diet
Reviewing status