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Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
Behav. Brain Res., DOI: 10.1016/j.bbr.2017.09.048 (2017)
DOI
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Gene Function Analysis ; Mouse Model ; Mouse Phenotyping ; Phenotyping Pipeline
ISSN (print) / ISBN 0166-4328
e-ISSN 1872-7549
Zeitschrift Behavioural Brain Research
Verlag Elsevier
Begutachtungsstatus peer-reviewed