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Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
Behav. Brain Res. 352, 187-196 (2017)
DOI
online verfügbar vsl. 04/2019 
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mouse Phenotyping ; Phenotyping Pipeline ; Mouse Model ; Gene Function Analysis; Parkinsons-disease; Mice; Models; Homeostasis; Consortium; Disorders; Infection; Platform
ISSN (print) / ISBN 0166-4328
e-ISSN 1872-7549
Zeitschrift Behavioural Brain Research
Quellenangaben Band: 352, Heft: , Seiten: 187-196 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Po Box 211, 1000 Ae Amsterdam, Netherlands
Begutachtungsstatus peer-reviewed