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Proteomics landscape of radiation-induced cardiovascular disease: Somewhere over the paradigm.

Expert Rev. Proteomics 14, 987-996 (2017)
Postprint DOI
Open Access Green
as soon as is submitted to ZB.
Introduction: Epidemiological studies clearly show that thoracic or whole body exposure to ionizing radiation increases the risk of cardiac morbidity and mortality. Radiation-induced cardiovascular disease (CVD) has been intensively studied during the last ten years but the underlying molecular mechanisms are still poorly understood. Areas covered: Heart proteomics is a powerful tool holding promise for the future research. The central focus of this review is to compare proteomics data on radiation-induced CVD with data arising from proteomics of healthy and diseased cardiac tissue in general. In this context we highlight common and unique features of radiation-related and other heart pathologies. Future prospects and challenges of the field are discussed. Expert commentary: Data from comprehensive cardiac proteomics have deepened the knowledge of molecular mechanisms involved in radiation-induced cardiac dysfunction. State-of-the-art proteomics has the potential to identify novel diagnostic and therapeutic markers of this disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Endothelial Cell ; Fibrates ; Heart ; Ionizing Radiation ; Label-free ; Ppar Alpha ; Proteomics ; Radiation Therapy ; Statins; Activated Receptor-alpha; Ischemic-heart-disease; Fatty-acid Oxidation; Extracellular-matrix Proteomics; Microvascular Endothelial-cells; Alkaline-phosphatase Activity; Cardiac Energy-metabolism; Myosin Heavy-chain; Low-dose Rate; Ionizing-radiation
Reviewing status