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Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes.
Horm. Mol. Biol. Clin. Investig. 31:0043 (2017)
DOI Verlagsversion bestellen
The dramatically increasing world-wide prevalence of obesity is recognized as a risk factor for the development of various diseases. The growing research on the role of adipose tissue in controlling energy homeostasis and insulin sensitivity has revealed that the promotion of brown adipose tissue (BAT) activity and the browning of white adipose tissue (WAT) leads to multiple health benefits and prevents obesity and type 2 diabetes (T2D). Inducible thermogenic adipocytes do exist in adult humans and are linked with increased energy combustion and lower body fat mass. Thus brown adipocytes are currently placed at the center of attention for novel therapeutic strategies against metabolic diseases such as obesity and diabetes. Besides the classical, norepinephrine-mediated sympathetic recruitment and activation of thermogenic adipocytes, a number of novel circulating factors have been recently identified to have a positive or negative impact on thermogenic adipocyte formation and activity. In this review their mechanism of action and the plausible therapeutic applications will be summarized and discussed.
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Publikationstyp Artikel: Journalartikel
Schlagwörter Bat-derived Factors ; Brown Adipose Tissue ; Endocrine/paracrine/autocrine Factors ; Thermogenesis
ISSN (print) / ISBN 1868-1883
Quellenangaben Band: 31, Heft: 2, Artikelnummer: 0043
Verlag de Gruyter
Verlagsort Berlin ; Boston, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)