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St John-Williams, L.* ; Blach, C.* ; Toledo, J.B.* ; Rotroff, D.M.* ; Kim, S.* ; Klavins, K.* ; Baillie, R.A.* ; Han, X.* ; MahmoudianDehkordi, S.* ; Jack, J.R.* ; Massaro, T.J.* ; Lucas, J.E.* ; Louie, G.* ; Motsinger-Reif, A.A.* ; Risacher, S.L.* ; Saykin, A.J.* ; Kastenmüller, G. ; Arnold, M. ; Koal, T.* ; Moseley, M.A.* ; Mangravite, L.M.* ; Peters, M.A.* ; Tenenbaum, J.D.* ; Thompson, J.W.* ; Kaddurah-Daouk, R.*

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort.

Sci. Data 4:170140 (2017)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Alzheimer's disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Alzheimer Disease Neuroimaging Initiative (ADNI) is creating a comprehensive biochemical database for AD. Using targeted and non- targeted metabolomics and lipidomics platforms we are mapping metabolic pathway and network failures across the trajectory of disease. In this report we present quantitative metabolomics data generated on serum from 199 control, 356 mild cognitive impairment and 175 AD subjects enrolled in ADNI1 using AbsoluteIDQ-p180 platform, along with the pipeline for data preprocessing and medication classification for confound correction. The dataset presented here is the first of eight metabolomics datasets being generated for broad biochemical investigation of the AD metabolome. We expect that these collective metabolomics datasets will provide valuable resources for researchers to identify novel molecular mechanisms contributing to AD pathogenesis and disease phenotypes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Global Biochemical Approach; Blood Metabolite Markers; Alzheimers-disease; Mass-spectrometry; Drug Response; Frequencies; Biomarker
ISSN (print) / ISBN 2052-4463
e-ISSN 2052-4463
Zeitschrift Scientific Data
Quellenangaben Band: 4, Heft: , Seiten: , Artikelnummer: 170140 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed