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Burger, K.* ; Ilicic, K.* ; Dierolf, M.* ; Günther, B.* ; Walsh, D.W.M.* ; Schmid, E.* ; Eggl, E.* ; Achterhold, K.* ; Gleich, B.* ; Combs, S.E. ; Molls, M. ; Schmid, T.E. ; Pfeiffer, F.* ; Wilkens, J.J.

Increased cell survival and cytogenetic integrity by spatial dose redistribution at a compact synchrotron X-ray source.

PLoS ONE 12:e0186005 (2017)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
X-ray microbeam radiotherapy can potentially widen the therapeutic window due to a geometrical redistribution of the dose. However, high requirements on photon flux, beam collimation, and system stability restrict its application mainly to large-scale, cost-intensive synchrotron facilities. With a unique laser-based Compact Light Source using inverse Compton scattering, we investigated the translation of this promising radiotherapy technique to a machine of future clinical relevance. We performed in vitro colony-forming assays and chromosome aberration tests in normal tissue cells after microbeam irradiation compared to homogeneous irradiation at the same mean dose using 25 keV X-rays. The microplanar pattern was achieved with a tungsten slit array of 50 μm slit size and a spacing of 350 μm. Applying microbeams significantly increased cell survival for a mean dose above 2 Gy, which indicates fewer normal tissue complications. The observation of significantly less chromosome aberrations suggests a lower risk of second cancer development. Our findings provide valuable insight into the mechanisms of microbeam radiotherapy and prove its applicability at a compact synchrotron, which contributes to its future clinical translation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Microbeam Radiation-therapy; Bystander; Carcinoma; Protons; Damage
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 12, Issue: 10, Pages: , Article Number: e0186005 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed