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Ludwig, B. ; Ludwig, S.* ; Steffen, A. ; Knauf, Y.* ; Zimerman, B.* ; Heinke, S.* ; Lehmann, S.* ; Schubert, U.* ; Schmid, J.* ; Bleyer, M.* ; Schoenmann, U.* ; Colton, C.K.* ; Bonifacio, E.* ; Solimena, M. ; Reichel, A.* ; Schally, A.V.* ; Rotem, A.* ; Barkai, U.* ; Grinberg-Rashi, H.* ; Kaup, F.* ; Avni, Y.* ; Jones, P.* ; Bornstein, S.R.

Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.

Proc. Natl. Acad. Sci. U.S.A. 114, 11745-11750 (2017)
Verlagsversion DOI
Free by publisher
Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macro-encapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diabetes ; Porcine Islets ; Beta-cell Replacement ; Immune Barrier; Hormone-releasing-hormone; Beta-cell Replacement; Bioartificial Pancreas; Transplantation; Future; Minipigs; Agonists
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Quellenangaben Band: 114, Heft: 44, Seiten: 11745-11750 Artikelnummer: , Supplement: ,
Verlag National Academy of Sciences
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)