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Krauze, A.* ; Attia, A.* ; Braunstein, S.* ; Chan, M.* ; Combs, S.E. ; Fietkau, R.* ; Fiveash, J.* ; Flickinger, J.* ; Grosu, A.-L.* ; Howard, S.* ; Nieder, C.* ; Niyazi, M.* ; Rowe, L.* ; Smart, D.D.* ; Tsien, C.* ; Camphausen, K.*

Expert consensus on re-irradiation for recurrent glioma.

Radiat. Oncol. 12:194 (2017)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Purpose: To investigate radiation oncologists' opinions on important considerations to offering re-irradiation (re-RT) as a treatment option for recurrent glioma. Materials and methods: A survey was conducted with 13 radiation oncologists involved in the care of central nervous system tumor patients. The survey was comprised of 49 questions divided into 2 domains: a demographic section (10 questions) and a case section (5 re-RT cases with 5 to 6 questions representing one or several re-RT treatment dilemmas as may be encountered in the clinic). Respondents were asked to rate the relevance of various factors to offering re-RT, respond to the cases with a decision to offer re-RT vs. not, volume to be treated, margins to be employed, dose/fractionation suggested and any additional comments with respect to rationale in each scenario. Results: Sixty nine percent of responders have been practicing for greater than 10years and 61% have re-RT 20 to 100 patients to date, with 54% seeing 2-5 re-RT cases per month and retreating 1-2 patients per month. Recurrent tumor volume, time since previous radiation therapy, previously administered dose to organs at risk and patient performance status were rated by the majority of responders (85%, 92%, 77%, and 69% respectively) as extremely relevant or very relevant to offering re-RT as an option. Conclusion: The experts' practice of re-RT is still heterogeneous, reflecting the paucity of high-quality prospective data available for decision-making. Nevertheless, practicing radiation oncologists can support own decisions by referring to the cases found suitable for re-RT in this survey.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Stereotactic Radiation-therapy; High-grade Gliomas; Radiotherapy; Glioblastoma; Management
ISSN (print) / ISBN 1748-717X
e-ISSN 1748-717X
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 194 Supplement: ,
Publisher BioMed Central
Publishing Place London
Reviewing status Peer reviewed