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Assessing sociability, social memory, and pup retrieval in mice.
Curr. Protoc. Mouse Biol. 7, 287-305 (2017)
Adaptive social behavior is important in mammals, both for the well-being of the individual and for the thriving of the species. Dysfunctions in social behavior occur in many neurodevelopmental and psychiatric diseases, and research into the genetic components of disease-relevant social deficits can open up new avenues for understanding the underlying biological mechanisms and therapeutic interventions. Genetically modified mouse models are particularly useful in this respect, and robust experimental protocols are needed to reliably assess relevant social behavior phenotypes. Here we describe in detail three protocols to quantitatively measure sociability, one of the most frequently investigated social behavior phenotypes in mice, using a three-chamber sociability test. These protocols can be extended to also assess social memory. In addition, we provide a detailed protocol on pup retrieval, which is a particularly robust maternal behavior amenable to various scientific questions. © 2017 by John Wiley & Sons, Inc.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Mice ; Pup Retrieval ; Social Behavior ; Social Memory ; Three-chamber Sociability Cage
ISSN (print) / ISBN 2161-2617
Quellenangaben Volume: 7, Issue: 7, Pages: 287-305
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)