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Meisinger, C. ; Rückert, I.-M. ; Rathmann, W.* ; Döring, A. ; Thorand, B. ; Huth, C. ; Kowall, B.* ; Koenig, W.*

Retinol-binding protein 4 is associated with prediabetes in adults from the general population: The Cooperative Health Research in the Region of Augsburg (KORA) F4 Study.

Diabetes Care 34, 1648-1650 (2011)
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE: We examined the association between retinol-binding protein 4 (RBP4), a novel adipokine, and prediabetes (isolated impaired fasting glucose [i-IFG], isolated impaired glucose tolerance [i-IGT], and combined IFG and IGT) in men and women aged 32-81 years. RESEARCH DESIGN AND METHODS: The analysis was based on 2,614 participants without previously diagnosed diabetes and those with newly diagnosed diabetes of the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study, conducted from 2006 to 2008 in southern Germany. Plasma RBP4 was analyzed by immunonephelometry. RESULTS: In logistic regression analysis, RBP4 levels in the fourth quartile versus the first quartile were significantly associated with prediabetes (i-IGT, i-IFG, and IFG/IGT; reference normal glucose tolerance) independent of known metabolic risk factors and lifestyle variables (odds ratio 1.63 [95% CI 1.17-2.27] after multivariable adjustment). Stratification by sex showed generally similar results. CONCLUSIONS: RBP4 levels were associated with prediabetes in individuals from the general population. Prospective studies investigating the impact of RBP4 on the development of glucose intolerance are needed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Impaired glucose-tolerance; Insulin-resistance; Diabetes-mellitus; Retinol-binding-protein-4; Obese; Women
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 34, Issue: 7, Pages: 1648-1650 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed