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Abbas, K.* ; Cydzik, I.* ; Del Torchio, R.* ; Farina, M.* ; Forti, E.* ; Gibson, N.* ; Holzwarth, U.* ; Simonelli, F.* ; Kreyling, W.G.

Radiolabelling of TiO₂ nanoparticles for radiotracer studies.

J. Nanopart. Res. 12, 2435-2443 (2010)
Postprint DOI
Open Access Green
Industrially manufactured titanium dioxide nanoparticles have been successfully radiolabelled with V-48 by irradiation with a cyclotron-generated proton beam. Centrifugation tests showed that the V-48 radiolabels were stably bound within the nanoparticle structure in an aqueous medium, while X-ray diffraction indicated that no major structural modifications to the nanoparticles resulted from the proton irradiation. In vitro tests of the uptake of cold and radiolabelled nanoparticles using the human cell line Calu-3 showed no significant difference in the uptake between both batches of nanoparticles. The uptake was quantified by Inductively Coupled Plasma Mass Spectrometry and high resolution gamma-ray spectrometry for cold and radiolabelled nanoparticles, respectively. These preliminary results indicate that alterations to the nanoparticles' properties introduced by proton bombardment can be controlled to a sufficient extent that their further use as radiotracers for biological investigations can be envisaged and elaborated.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nanoparticles; Radiolabelling; Titanium dioxide; In vitro; Cell uptake; Nanomanufacturing; Nanomedicine
ISSN (print) / ISBN 1388-0764
e-ISSN 1572-896X
Quellenangaben Band: 12, Heft: 7, Seiten: 2435-2443 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin [u.a.]
Begutachtungsstatus Peer reviewed