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O’Leary, V.B.* ; O’Connell, M.* ; Antyborzec, I.* ; Ntziachristos, V. ; Oliver Dolly, J.* ; Ovsepian, S.V.

Alleviation of trigeminal nociception using p75 neurotrophin receptor targeted lentiviral interference therapy.

Neurotherapeutics 15, 489-499 (2018)
Verlagsversion Forschungsdaten DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter P75ntr ; Capsaicin ; Trpv1 ; Neuropathic Pain ; Neurotherapeutics; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN 1933-7213
e-ISSN 1878-7479
Zeitschrift Neurotherapeutics
Quellenangaben Band: 15, Heft: 2, Seiten: 489-499 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed