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Lorentzen, A.R. ; Becker, P.F. ; Kosla, J. ; Saini, M.* ; Weidele, K.* ; Ronchi, P.* ; Klein, C.* ; Wolf, M.J.* ; Geist, F.* ; Seubert, B. ; Ringelhan, M. ; Mihic-Probst, D.* ; Esser, K. ; Roblek, M.* ; Kuehne, F. ; Bianco, G. ; O'Connor, T. ; Müller, Q.* ; Schuck, K.* ; Lange, S.* ; Hartmann, D.* ; Spaich, S.* ; Groß, O.* ; Utikal, J.* ; Haferkamp, S.* ; Sprick, M.R.* ; Damle-Vartak, A.* ; Hapfelmeier, A.* ; Hüser, N.* ; Protzer, U. ; Trumpp, A.* ; Saur, D.* ; Vartak, N.* ; Klein, C.A.* ; Polzer, B.* ; Borsig, L.* ; Heikenwälder, M.

Single cell polarity in liquid phase facilitates tumour metastasis.

Nat. Commun. 9:887 (2018)
Publ. Version/Full Text Research data Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cancer; Adhesion; Melanoma; Resistance; Cd146; Erm; Contractility; Progression; Mechanisms; Expression
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Quellenangaben Volume: 9, Issue: 1, Pages: , Article Number: 887 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed