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Monzón-Casanova, E.* ; Screen, M.* ; Díaz-Muñoz, M.D.* ; Coulson, R.M.R.* ; Bell, S.E.* ; Lamers, G.* ; Solimena, M. ; Smith, C.W.J.* ; Turner, M.*

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.

Nat. Immunol. 19, 267–278 (2018)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from helper T cells, which promotes their rapid proliferation. Here we found that the RNA-binding protein PTBP1 was needed for the progression of GC B cells through late S phase of the cell cycle and for affinity maturation. PTBP1 was required for proper expression of the c-MYC-dependent gene program induced in GC B cells receiving T cell help and directly regulated the alternative splicing and abundance of transcripts that are increased during positive selection to promote proliferation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter C-myc; Affinity Maturation; Dynamic Regulation; Center Light; Expression; Kinase; Mouse; Gene; Proliferation; Regulator
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Zeitschrift Nature Immunology
Quellenangaben Band: 19, Heft: 3, Seiten: 267–278 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)