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Apweiler, R.* ; Beissbarth, T.* ; Berthold, M.R.* ; Blüthgen, N.* ; Burmeister, Y.* ; Dammann, O.* ; Deutsch, A.J.* ; Feuerhake, F.* ; Franke, A.* ; Hasenauer, J. ; Hoffmann, S.* ; Höfer, T.* ; Jansen, P.L.M.* ; Kaderali, L.* ; Klingmüller, U.* ; Koch, I.* ; Kohlbacher, O.* ; Kuepfer, L.* ; Lammert, F.* ; Maier, D.* ; Pfeifer, N.* ; Radde, N.* ; Rehm, M.* ; Roeder, I.* ; Saez-Rodriguez, J.* ; Sax, U.* ; Schmeck, B.T.* ; Schuppert, A.* ; Seilheimer, B.* ; Theis, F.J. ; Vera, J.* ; Wolkenhauer, O.*

Whither systems medicine?

Exp. Mol. Med. 50:e453 (2018)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.
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Publication type Article: Journal article
Document type Review
Keywords Single-cell Analysis; Colorectal-cancer; Big Data; Pharmacology; Biology; Generation; Mechanisms; Models; Tools
ISSN (print) / ISBN 1226-3613
e-ISSN 2092-6413
Quellenangaben Volume: 50, Issue: 3, Pages: , Article Number: e453 Supplement: ,
Publisher Macmillan Publishers
Publishing Place Seoul
Reviewing status