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Cutaneous barriers and skin immunity: Differentiating a connected network.

Trends Immunol. 39, 315-327 (2018)
Postprint DOI
Open Access Green
as soon as is submitted to ZB.
The skin is the outermost barrier of the organism that ensures protection from external harm. Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ that can sense danger signals and mount perfectly adapted defense measures in response to invading pathogens. This Review highlights the different levels of the cutaneous barrier (the microbiome, chemical, physical, and immune barriers), their characteristics, and functional, highly interconnected network of cells and mediators that allow balanced defense measures to protect the body and maintain barrier integrity.
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Publication type Article: Journal article
Document type Review
Keywords Innate Lymphoid-cells; Memory T-cells; Epidermal Tight-junctions; Stratum-corneum Lipids; Atopic-dermatitis; Staphylococcus-aureus; Epithelial-cells; Dendritic Cells; Wound Repair; Mast-cells
Reviewing status
Institute(s) Institute for Allergy Research (IAF)
Institute of Environmental Medicine (IEM)