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Cutaneous barriers and skin immunity: Differentiating a connected network.

Trends Immunol. 39, 315-327 (2018)
Publ. Version/Full Text Postprint DOI
Open Access Green
The skin is the outermost barrier of the organism that ensures protection from external harm. Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ that can sense danger signals and mount perfectly adapted defense measures in response to invading pathogens. This Review highlights the different levels of the cutaneous barrier (the microbiome, chemical, physical, and immune barriers), their characteristics, and functional, highly interconnected network of cells and mediators that allow balanced defense measures to protect the body and maintain barrier integrity.
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Publication type Article: Journal article
Document type Review
Keywords Innate Lymphoid-cells; Memory T-cells; Epidermal Tight-junctions; Stratum-corneum Lipids; Atopic-dermatitis; Staphylococcus-aureus; Epithelial-cells; Dendritic Cells; Wound Repair; Mast-cells
ISSN (print) / ISBN 1471-4906
e-ISSN 1471-4981
Quellenangaben Volume: 39, Issue: 4, Pages: 315-327 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)
Institute of Environmental Medicine (IEM)
Unit for Clinical Allergology (KKG-EKA)