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Olefir, I. ; Tzoumas, S.* ; Yang, H. ; Ntziachristos, V.

A bayesian approach to eigenspectra optoacoustic tomography.

IEEE Trans. Med. Imaging 37, 2070-2079 (2018)
Postprint DOI
Open Access Green
The quantification of hemoglobin oxygen saturation (sO(2)) with multispectral optoacoustic (OA) (photoacoustic) tomography (MSOT) is a complex spectral unmixing problem, since the OA spectra of hemoglobin are modified with tissue depth due to depth (location) and wavelength dependencies of optical fluence in tissue. In a recent work, a method termed eigenspectra MSOT (eMSOT) was proposed for addressing the dependence of spectra on fluence and quantifying blood sO(2) in deep tissue. While eMSOT offers enhanced sO(2) quantification accuracy over conventional unmixing methods, its performance may be compromised by noise and image reconstruction artifacts. In this paper, we propose a novel Bayesian method to improve eMSOT performance in noisy environments. We introduce a spectral reliability map, i.e., a method that can estimate the level of noise superimposed onto the recorded OA spectra. Using this noise estimate, we formulate eMSOT as a Bayesian inverse problem where the inversion constraints are based on probabilistic graphical models. Results based on numerical simulations indicate that the proposed method offers improved accuracy and robustness under high noise levels due the adaptive nature of the Bayesian method.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Optoacoustic/photoacoustic Imaging ; Multispectral Optoacoustic Tomography ; Photoacoustic Tomography ; Bayesian Methods ; Oxygen Saturation ; Spectral Unmixing; Quantitative Photoacoustic Tomography; Image-reconstruction; Model; Distributions; Challenges; Deep; Map
ISSN (print) / ISBN 0278-0062
e-ISSN 1558-254X
Quellenangaben Volume: 37, Issue: 9, Pages: 2070-2079 Article Number: , Supplement: ,
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Publishing Place New York, NY [u.a.]
Reviewing status Peer reviewed