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Localization optoacoustic tomography.

Light Sci. Appl. 7, 18004:18004 (2018)
Verlagsversion Postprint DOI
Open Access Gold
Creative Commons Lizenzvertrag
Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues. Herein, we introduce a new concept of localization optoacoustic tomography (LOT) that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles. We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions. Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters, LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Acoustic Diffraction ; Limited-view Effects ; Localization ; Optoacoustic Imaging ; Photoacoustic Imaging ; Super-resolution
ISSN (print) / ISBN 2047-7538
e-ISSN 2047-7538
Quellenangaben Band: 7, Heft: , Seiten: 18004 Artikelnummer: 18004 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed