PuSH - Publikationsserver des Helmholtz Zentrums München

Gennaro, G.* ; Avramova-Cholakova, S.* ; Azzalini, A.* ; Luisa Chapel, M.* ; Chevalier, M.* ; Ciraj, O.* ; de las Heras Gala, H. ; Gershan, V.* ; Hemdal, B.* ; Keavey, E.* ; Lanconelli, N.* ; Menhart, S.* ; João Fartaria, M.* ; Pascoal, A.* ; Pedersen, K.* ; Rivetti, S.* ; Rossetti, V.* ; Semturs, F.* ; Sharp, P.* ; Torresin, A.*

Quality controls in digital mammography protocol of the EFOMP mammo working group.

Phys. Med. 48, 55-64 (2018)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Flatworms of the species Schmidtea mediterranea are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Digital Mammography ; Quality Control ; Protocol ; Efomp; Planarian Schmidtea-mediterranea; Stem-cells; Rna-seq; Gene-expression; Regeneration; Pluripotency; Trajectories; Organism; Tissues; System
ISSN (print) / ISBN 1120-1797
e-ISSN 1724-191X
Quellenangaben Band: 48, Heft: , Seiten: 55-64 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed