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hIAPP forms toxic oligomers in plasma.

Chem. Commun. 54, 5426-5429 (2018)
Postprint DOI PMC
Open Access Green
In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0009-241X
e-ISSN 1364-548X
Zeitschrift Chemical Communications
Quellenangaben Band: 54, Heft: 43, Seiten: 5426-5429 Artikelnummer: , Supplement: ,
Verlag Royal Society of Chemistry (RSC)