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hIAPP forms toxic oligomers in plasma.

Chem. Commun. 54, 5426-5429 (2018)
Postprint DOI PMC
Open Access Green
as soon as is submitted to ZB.
In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
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Publication type Article: Journal article
Document type Scientific Article
Reviewing status