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Gradl, R.* ; Dierolf, M.* ; Guenther, B.* ; Hehn, L.* ; Möller, W. ; Kutschke, D. ; Yang, L. ; Donnelley, M.* ; Murrie, R.* ; Erl, A. ; Stöger, T. ; Gleich, B.* ; Achterhold, K.* ; Schmid, O. ; Pfeiffer, F.* ; Morgan, K.S.*

In vivo dynamic phase-contrast X-ray Imaging using a compact light source.

Sci. Rep. 8:6788 (2018)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 8, Heft: 1, Seiten: , Artikelnummer: 6788 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed